Roger D. Winland
2018 September/October; 66(5):5.

Mark J. Barnes 
Eliana Dantas da Costa
Gina Delia Roque-Torres
Priscila Dias Peyneau
Luís Roberto Godolfim
Francisco Haiter Neto
Solange Maria de Almeida 
2018 September/October; 66(5):6, 8.

Samuel M. Strong
2018 September/October; 66(5):10-13.

Jason H. Goodchild
Mark Donaldson 
2018 September/October; 66(5):14-16.

Mark I. Malterud
2018 September/October; 66(5):17-19.

Jessica L. Owens
Danielle A. Beaudoin
Christopher J. Spencer
2018 September/October; 66(5):20-23.

Preetha Kanjirath
Larry Williams
2018 September/October; 66(5):24-25.

Galal Omami 
2018 September/October; 66(5):77-78.

Milda Chmieliauskaite
Ivan Stojanov 
Mana Saraghi
Andres Pinto 

Targeted therapies are so-named due to their targeting of dysregulated signaling pathways in cancer cells. This discrimination between tumor and normal cells is a more efficacious approach to treatment than conventional, cytotoxic chemotherapy. However, targeted therapies still have side effects, and some manifest in the oral cavity. This article reviews the oral adverse effects associated with targeted chemotherapeutic agents as well as management approaches.

2018 September/October; 66(5):26-31.

Helena M. Swank
Nancy C. Motyka
Clifton W. Bailey
Kraig S. Vandewalle

This study evaluated the shear bond strength (SBS) of a resin cement to a glass-ceramic material pretreated with combination treatment solutions or the traditional approach of hydrofluoric acid (HF) and silane (control). Pretreatment of the glass ceramic with HF and silane resulted in a significantly greater mean SBS than did any of the combination solutions, which were not significantly different from each other. In the experimental groups with simplified pretreatments, specimen failures were mostly due to adhesive fractures. In the control group the mode of failure was more often mixed adhesive-cohesive fracture.

2018 September/October; 66(5):33-37.

Formation of biofilm on various implant abutment materials
Nasrin Esfahanizadeh  
Seyedeh Pegah Mirmalek
Abbas Bahador
Hamidreza Daneshparvar
Nasrin Akhoundi 
Maryam Pourhajibagher

Biofilm formation induced by bacterial suspensions on laser-treated titanium, zirconia, and titanium surfaces was measured in vitro. The abutment material type, the bacteria type, and their interactions had significant effects on the bacterial counts. The highest counts of periodontal pathogens were found on laser-treated surfaces, while the intermediate and lowest counts were on zirconia and titanium surfaces, respectively.

2018 September/October; 66(5):39-44.

Caroline Nguyen Ngoc
Taneet Ghuman
Sumitha N. Ahmed
Terry E. Donovan

Water enhancers (WEs) have grown in popularity in recent years, but many have a high citric acid content. The purpose of this in vitro study was to determine the erosive potential of 7 WEs mixed in 3 different brands of bottled water. Experiments measured the pH and titratable acidity of the 21 combinations as well as the loss of mass from extracted human molars after 1 month of immersion in the solutions. Regardless of the brands, the addition of a WE to bottled water increased the potential for dental erosion, likely due to the high content of citric acid.

2018 September/October; 66(5):46-51.

Maria L. Geisinger
Amanda B. Morris
Maninder Kaur
Sonya L. Hardy
Ramzi V. Abou Arraj
Nicolaas C. Geurs
Michael S. Reddy

Outcomes for treatment, overall oral health status, and periodontal disease progression in patients with type 2 diabetes mellitus (T2DM) have been associated with glycemic control, as measured by hemoglobin A1c (HbA1c) levels. In this study, 70% of 214 patients who were under the care of a physician for T2DM were found to have an HbA1c level that was not ideal, and 53% of the patients with poor control had HbA1c levels high enough to require medical intervention. Dental healthcare providers should consider consultation and/or advanced screening for T2DM patients seeking dental care.

2018 September/October; 66(5):52-55.

Amber D. Riley

Before treating patients with implantable cardiac devices, dentists must identify the patient’s underlying medical condition and consider both the condition and device during diagnosis and treatment. Modern implantable devices are resistant to electromagnetic field changes, but dentists should use the greatest caution with electrocautery devices and choose a bipolar system whenever possible. Consultation with a patient’s physician is prudent prior to lengthy treatment or use of dental technology that produces an electromagnetic field.

2018 September/October; 66(5):56-60.

Sara Tomczyk
Tory Whitten 
Stacy M. Holzbauer 
Ruth Lynfield

A survey assessing antibiotic-prescribing practices among Minnesota dentists found that a median of 4 antibiotic prophylaxis and 5 treatment prescriptions per month were written by 437 survey respondents. Dentists reported prescribing antibiotics for prophylaxis before invasive dental procedures for patients with “high-risk conditions” (84%) and localized swelling (70%) as well as for a number of reasons that are not recommended by current prescribing guidelines. Antibiotic stewardship efforts in dentistry should address challenges to guideline adherence.

2018 September/October; 66(5):61-68.

Bruno Piazza 
Rodrigo R. Vivan 
Murilo P. Alcalde 
Marco Antonio H. Duarte 
Flaviana B. de Andrade 
Bruno Martini Guimarães 
Clovis M. Bramante

Accidental sodium hypochlorite extrusion during endodontic irrigation can result in severe pain, swelling, and probable tissue necrosis adjacent to the root. Conventional treatment involves saline irrigation as well as analgesic, anti-inflammatory, and antibiotic medications. This case report describes the addition of low-level laser therapy to conventional treatment as a means to improve healing after sodium hypochlorite extrusion caused soft tissue necrosis.

2018 September/October; 66(5):69-72.

Monika Pal
Kanishk Gupta
Santhosh Kumar
Pratibha G

Mandibular tori are an ideal site for harvesting bone because their excision causes no structural, esthetic, or functional compromise to the patient. This case report describes the use of an autogenous graft obtained from a mandibular torus to fill an intrabony defect at the mandibular right central incisor. The torus provided sufficient graft material and eliminated the need for a second surgical site. A follow-up at 1 year revealed reduction in clinical attachment loss and complete resolution of tooth mobility.

2018 September/October; 66(5):73-76.

Eliana Dantas da Costa
Priscila Dias Peyneau 
Liana Matos Ferreira
Matheus Lima Oliveira
Glaucia Maria Bovi Ambrosano 

Osteomas are benign, asymptomatic fibro-osseous tumors that are most commonly observed in the paranasal sinuses. A rare giant osteoma involving the frontal and ethmoid sinuses was found incidentally during a cone beam computed tomographic examination performed for orthodontic reasons. The case report discusses the characteristics of the tumor through cone beam computed tomography as well as options for treatment.

2018 September/October; 66(5):e1-e4.

Fábio Ramôa Pires
Cristiane Bouzada Bruzigueses Espíndola
Sebastião Helberto Ferreira Espíndola 
Juliana de Noronha Santos Netto

A 43-year-old man presented with a slight depression on the lingual surface of the anterior mandible associated with a well-defined radiolucent area superimposed on the roots of the right canine and incisors. All teeth in the area were vital, and cone beam computed tomography revealed a lingual depression in the area. The final diagnosis was an anterior lingual mandibular bone depression, and 22 months of follow-up examinations revealed no alterations in the area. When anterior mandibular radiolucencies are superimposed on the roots of the adjacent teeth, anterior lingual mandibular bone depressions should be considered in the differential diagnosis, along with periapical cysts and granulomas.

2018 September/October; 66(5):e6-e11.

Eliane Cristina Viana Revoredo
André Galembeck 
Elizabeth Arruda Carneiro Ponzi
Jair Carneiro Leão
Leonardo de Siqueira Arcoverde
Luciana Corrêa de Araújo Arcoverde
Sônia Pereira Leite

An immediate obturator is an important aid in the treatment of patients diagnosed with tumors of the head and neck. This case report demonstrates the advantages of using 3-dimensional prototyping in the planning and manufacture of a palatal obturator prosthesis after resection of an ameloblastoma in the left maxillary sinus.

2018 September/October; 66(5):e12-e17.

Roger D. Winland
2018 September/October; 66(5):5.

Mark J. Barnes 
Eliana Dantas da Costa
Gina Delia Roque-Torres
Priscila Dias Peyneau
Luís Roberto Godolfim
Francisco Haiter Neto
Solange Maria de Almeida 
2018 September/October; 66(5):6, 8.

Samuel M. Strong
2018 September/October; 66(5):10-13.

Jason H. Goodchild
Mark Donaldson 
2018 September/October; 66(5):14-16.

Mark I. Malterud
2018 September/October; 66(5):17-19.

Jessica L. Owens
Danielle A. Beaudoin
Christopher J. Spencer
2018 September/October; 66(5):20-23.

Preetha Kanjirath
Larry Williams
2018 September/October; 66(5):24-25.

Galal Omami 
2018 September/October; 66(5):77-78.

Milda Chmieliauskaite
Ivan Stojanov 
Mana Saraghi
Andres Pinto 

Targeted therapies are so-named due to their targeting of dysregulated signaling pathways in cancer cells. This discrimination between tumor and normal cells is a more efficacious approach to treatment than conventional, cytotoxic chemotherapy. However, targeted therapies still have side effects, and some manifest in the oral cavity. This article reviews the oral adverse effects associated with targeted chemotherapeutic agents as well as management approaches.

2018 September/October; 66(5):26-31.

Helena M. Swank
Nancy C. Motyka
Clifton W. Bailey
Kraig S. Vandewalle

This study evaluated the shear bond strength (SBS) of a resin cement to a glass-ceramic material pretreated with combination treatment solutions or the traditional approach of hydrofluoric acid (HF) and silane (control). Pretreatment of the glass ceramic with HF and silane resulted in a significantly greater mean SBS than did any of the combination solutions, which were not significantly different from each other. In the experimental groups with simplified pretreatments, specimen failures were mostly due to adhesive fractures. In the control group the mode of failure was more often mixed adhesive-cohesive fracture.

2018 September/October; 66(5):33-37.

Formation of biofilm on various implant abutment materials
Nasrin Esfahanizadeh  
Seyedeh Pegah Mirmalek
Abbas Bahador
Hamidreza Daneshparvar
Nasrin Akhoundi 
Maryam Pourhajibagher

Biofilm formation induced by bacterial suspensions on laser-treated titanium, zirconia, and titanium surfaces was measured in vitro. The abutment material type, the bacteria type, and their interactions had significant effects on the bacterial counts. The highest counts of periodontal pathogens were found on laser-treated surfaces, while the intermediate and lowest counts were on zirconia and titanium surfaces, respectively.

2018 September/October; 66(5):39-44.

Caroline Nguyen Ngoc
Taneet Ghuman
Sumitha N. Ahmed
Terry E. Donovan

Water enhancers (WEs) have grown in popularity in recent years, but many have a high citric acid content. The purpose of this in vitro study was to determine the erosive potential of 7 WEs mixed in 3 different brands of bottled water. Experiments measured the pH and titratable acidity of the 21 combinations as well as the loss of mass from extracted human molars after 1 month of immersion in the solutions. Regardless of the brands, the addition of a WE to bottled water increased the potential for dental erosion, likely due to the high content of citric acid.

2018 September/October; 66(5):46-51.

Maria L. Geisinger
Amanda B. Morris
Maninder Kaur
Sonya L. Hardy
Ramzi V. Abou Arraj
Nicolaas C. Geurs
Michael S. Reddy

Outcomes for treatment, overall oral health status, and periodontal disease progression in patients with type 2 diabetes mellitus (T2DM) have been associated with glycemic control, as measured by hemoglobin A1c (HbA1c) levels. In this study, 70% of 214 patients who were under the care of a physician for T2DM were found to have an HbA1c level that was not ideal, and 53% of the patients with poor control had HbA1c levels high enough to require medical intervention. Dental healthcare providers should consider consultation and/or advanced screening for T2DM patients seeking dental care.

2018 September/October; 66(5):52-55.

Amber D. Riley

Before treating patients with implantable cardiac devices, dentists must identify the patient’s underlying medical condition and consider both the condition and device during diagnosis and treatment. Modern implantable devices are resistant to electromagnetic field changes, but dentists should use the greatest caution with electrocautery devices and choose a bipolar system whenever possible. Consultation with a patient’s physician is prudent prior to lengthy treatment or use of dental technology that produces an electromagnetic field.

2018 September/October; 66(5):56-60.

Sara Tomczyk
Tory Whitten 
Stacy M. Holzbauer 
Ruth Lynfield

A survey assessing antibiotic-prescribing practices among Minnesota dentists found that a median of 4 antibiotic prophylaxis and 5 treatment prescriptions per month were written by 437 survey respondents. Dentists reported prescribing antibiotics for prophylaxis before invasive dental procedures for patients with “high-risk conditions” (84%) and localized swelling (70%) as well as for a number of reasons that are not recommended by current prescribing guidelines. Antibiotic stewardship efforts in dentistry should address challenges to guideline adherence.

2018 September/October; 66(5):61-68.

Bruno Piazza 
Rodrigo R. Vivan 
Murilo P. Alcalde 
Marco Antonio H. Duarte 
Flaviana B. de Andrade 
Bruno Martini Guimarães 
Clovis M. Bramante

Accidental sodium hypochlorite extrusion during endodontic irrigation can result in severe pain, swelling, and probable tissue necrosis adjacent to the root. Conventional treatment involves saline irrigation as well as analgesic, anti-inflammatory, and antibiotic medications. This case report describes the addition of low-level laser therapy to conventional treatment as a means to improve healing after sodium hypochlorite extrusion caused soft tissue necrosis.

2018 September/October; 66(5):69-72.

Monika Pal
Kanishk Gupta
Santhosh Kumar
Pratibha G

Mandibular tori are an ideal site for harvesting bone because their excision causes no structural, esthetic, or functional compromise to the patient. This case report describes the use of an autogenous graft obtained from a mandibular torus to fill an intrabony defect at the mandibular right central incisor. The torus provided sufficient graft material and eliminated the need for a second surgical site. A follow-up at 1 year revealed reduction in clinical attachment loss and complete resolution of tooth mobility.

2018 September/October; 66(5):73-76.

Eliana Dantas da Costa
Priscila Dias Peyneau 
Liana Matos Ferreira
Matheus Lima Oliveira
Glaucia Maria Bovi Ambrosano 

Osteomas are benign, asymptomatic fibro-osseous tumors that are most commonly observed in the paranasal sinuses. A rare giant osteoma involving the frontal and ethmoid sinuses was found incidentally during a cone beam computed tomographic examination performed for orthodontic reasons. The case report discusses the characteristics of the tumor through cone beam computed tomography as well as options for treatment.

2018 September/October; 66(5):e1-e4.

Fábio Ramôa Pires
Cristiane Bouzada Bruzigueses Espíndola
Sebastião Helberto Ferreira Espíndola 
Juliana de Noronha Santos Netto

A 43-year-old man presented with a slight depression on the lingual surface of the anterior mandible associated with a well-defined radiolucent area superimposed on the roots of the right canine and incisors. All teeth in the area were vital, and cone beam computed tomography revealed a lingual depression in the area. The final diagnosis was an anterior lingual mandibular bone depression, and 22 months of follow-up examinations revealed no alterations in the area. When anterior mandibular radiolucencies are superimposed on the roots of the adjacent teeth, anterior lingual mandibular bone depressions should be considered in the differential diagnosis, along with periapical cysts and granulomas.

2018 September/October; 66(5):e6-e11.

Eliane Cristina Viana Revoredo
André Galembeck 
Elizabeth Arruda Carneiro Ponzi
Jair Carneiro Leão
Leonardo de Siqueira Arcoverde
Luciana Corrêa de Araújo Arcoverde
Sônia Pereira Leite

An immediate obturator is an important aid in the treatment of patients diagnosed with tumors of the head and neck. This case report demonstrates the advantages of using 3-dimensional prototyping in the planning and manufacture of a palatal obturator prosthesis after resection of an ameloblastoma in the left maxillary sinus.

2018 September/October; 66(5):e12-e17.

Roger D. Winland
2018 September/October; 66(5):5.

Mark J. Barnes 
Eliana Dantas da Costa
Gina Delia Roque-Torres
Priscila Dias Peyneau
Luís Roberto Godolfim
Francisco Haiter Neto
Solange Maria de Almeida 
2018 September/October; 66(5):6, 8.

Samuel M. Strong
2018 September/October; 66(5):10-13.

Jason H. Goodchild
Mark Donaldson 
2018 September/October; 66(5):14-16.

Mark I. Malterud
2018 September/October; 66(5):17-19.

Jessica L. Owens
Danielle A. Beaudoin
Christopher J. Spencer
2018 September/October; 66(5):20-23.

Preetha Kanjirath
Larry Williams
2018 September/October; 66(5):24-25.

Galal Omami 
2018 September/October; 66(5):77-78.

Milda Chmieliauskaite
Ivan Stojanov 
Mana Saraghi
Andres Pinto 

Targeted therapies are so-named due to their targeting of dysregulated signaling pathways in cancer cells. This discrimination between tumor and normal cells is a more efficacious approach to treatment than conventional, cytotoxic chemotherapy. However, targeted therapies still have side effects, and some manifest in the oral cavity. This article reviews the oral adverse effects associated with targeted chemotherapeutic agents as well as management approaches.

2018 September/October; 66(5):26-31.

Helena M. Swank
Nancy C. Motyka
Clifton W. Bailey
Kraig S. Vandewalle

This study evaluated the shear bond strength (SBS) of a resin cement to a glass-ceramic material pretreated with combination treatment solutions or the traditional approach of hydrofluoric acid (HF) and silane (control). Pretreatment of the glass ceramic with HF and silane resulted in a significantly greater mean SBS than did any of the combination solutions, which were not significantly different from each other. In the experimental groups with simplified pretreatments, specimen failures were mostly due to adhesive fractures. In the control group the mode of failure was more often mixed adhesive-cohesive fracture.

2018 September/October; 66(5):33-37.

Formation of biofilm on various implant abutment materials
Nasrin Esfahanizadeh  
Seyedeh Pegah Mirmalek
Abbas Bahador
Hamidreza Daneshparvar
Nasrin Akhoundi 
Maryam Pourhajibagher

Biofilm formation induced by bacterial suspensions on laser-treated titanium, zirconia, and titanium surfaces was measured in vitro. The abutment material type, the bacteria type, and their interactions had significant effects on the bacterial counts. The highest counts of periodontal pathogens were found on laser-treated surfaces, while the intermediate and lowest counts were on zirconia and titanium surfaces, respectively.

2018 September/October; 66(5):39-44.

Caroline Nguyen Ngoc
Taneet Ghuman
Sumitha N. Ahmed
Terry E. Donovan

Water enhancers (WEs) have grown in popularity in recent years, but many have a high citric acid content. The purpose of this in vitro study was to determine the erosive potential of 7 WEs mixed in 3 different brands of bottled water. Experiments measured the pH and titratable acidity of the 21 combinations as well as the loss of mass from extracted human molars after 1 month of immersion in the solutions. Regardless of the brands, the addition of a WE to bottled water increased the potential for dental erosion, likely due to the high content of citric acid.

2018 September/October; 66(5):46-51.

Maria L. Geisinger
Amanda B. Morris
Maninder Kaur
Sonya L. Hardy
Ramzi V. Abou Arraj
Nicolaas C. Geurs
Michael S. Reddy

Outcomes for treatment, overall oral health status, and periodontal disease progression in patients with type 2 diabetes mellitus (T2DM) have been associated with glycemic control, as measured by hemoglobin A1c (HbA1c) levels. In this study, 70% of 214 patients who were under the care of a physician for T2DM were found to have an HbA1c level that was not ideal, and 53% of the patients with poor control had HbA1c levels high enough to require medical intervention. Dental healthcare providers should consider consultation and/or advanced screening for T2DM patients seeking dental care.

2018 September/October; 66(5):52-55.

Amber D. Riley

Before treating patients with implantable cardiac devices, dentists must identify the patient’s underlying medical condition and consider both the condition and device during diagnosis and treatment. Modern implantable devices are resistant to electromagnetic field changes, but dentists should use the greatest caution with electrocautery devices and choose a bipolar system whenever possible. Consultation with a patient’s physician is prudent prior to lengthy treatment or use of dental technology that produces an electromagnetic field.

2018 September/October; 66(5):56-60.

Sara Tomczyk
Tory Whitten 
Stacy M. Holzbauer 
Ruth Lynfield

A survey assessing antibiotic-prescribing practices among Minnesota dentists found that a median of 4 antibiotic prophylaxis and 5 treatment prescriptions per month were written by 437 survey respondents. Dentists reported prescribing antibiotics for prophylaxis before invasive dental procedures for patients with “high-risk conditions” (84%) and localized swelling (70%) as well as for a number of reasons that are not recommended by current prescribing guidelines. Antibiotic stewardship efforts in dentistry should address challenges to guideline adherence.

2018 September/October; 66(5):61-68.

Bruno Piazza 
Rodrigo R. Vivan 
Murilo P. Alcalde 
Marco Antonio H. Duarte 
Flaviana B. de Andrade 
Bruno Martini Guimarães 
Clovis M. Bramante

Accidental sodium hypochlorite extrusion during endodontic irrigation can result in severe pain, swelling, and probable tissue necrosis adjacent to the root. Conventional treatment involves saline irrigation as well as analgesic, anti-inflammatory, and antibiotic medications. This case report describes the addition of low-level laser therapy to conventional treatment as a means to improve healing after sodium hypochlorite extrusion caused soft tissue necrosis.

2018 September/October; 66(5):69-72.

Monika Pal
Kanishk Gupta
Santhosh Kumar
Pratibha G

Mandibular tori are an ideal site for harvesting bone because their excision causes no structural, esthetic, or functional compromise to the patient. This case report describes the use of an autogenous graft obtained from a mandibular torus to fill an intrabony defect at the mandibular right central incisor. The torus provided sufficient graft material and eliminated the need for a second surgical site. A follow-up at 1 year revealed reduction in clinical attachment loss and complete resolution of tooth mobility.

2018 September/October; 66(5):73-76.

Eliana Dantas da Costa
Priscila Dias Peyneau 
Liana Matos Ferreira
Matheus Lima Oliveira
Glaucia Maria Bovi Ambrosano 

Osteomas are benign, asymptomatic fibro-osseous tumors that are most commonly observed in the paranasal sinuses. A rare giant osteoma involving the frontal and ethmoid sinuses was found incidentally during a cone beam computed tomographic examination performed for orthodontic reasons. The case report discusses the characteristics of the tumor through cone beam computed tomography as well as options for treatment.

2018 September/October; 66(5):e1-e4.

Fábio Ramôa Pires
Cristiane Bouzada Bruzigueses Espíndola
Sebastião Helberto Ferreira Espíndola 
Juliana de Noronha Santos Netto

A 43-year-old man presented with a slight depression on the lingual surface of the anterior mandible associated with a well-defined radiolucent area superimposed on the roots of the right canine and incisors. All teeth in the area were vital, and cone beam computed tomography revealed a lingual depression in the area. The final diagnosis was an anterior lingual mandibular bone depression, and 22 months of follow-up examinations revealed no alterations in the area. When anterior mandibular radiolucencies are superimposed on the roots of the adjacent teeth, anterior lingual mandibular bone depressions should be considered in the differential diagnosis, along with periapical cysts and granulomas.

2018 September/October; 66(5):e6-e11.

Eliane Cristina Viana Revoredo
André Galembeck 
Elizabeth Arruda Carneiro Ponzi
Jair Carneiro Leão
Leonardo de Siqueira Arcoverde
Luciana Corrêa de Araújo Arcoverde
Sônia Pereira Leite

An immediate obturator is an important aid in the treatment of patients diagnosed with tumors of the head and neck. This case report demonstrates the advantages of using 3-dimensional prototyping in the planning and manufacture of a palatal obturator prosthesis after resection of an ameloblastoma in the left maxillary sinus.

2018 September/October; 66(5):e12-e17.

Roger D. Winland
2018 September/October; 66(5):5.

Mark J. Barnes 
Eliana Dantas da Costa
Gina Delia Roque-Torres
Priscila Dias Peyneau
Luís Roberto Godolfim
Francisco Haiter Neto
Solange Maria de Almeida 
2018 September/October; 66(5):6, 8.

Samuel M. Strong
2018 September/October; 66(5):10-13.

Jason H. Goodchild
Mark Donaldson 
2018 September/October; 66(5):14-16.

Mark I. Malterud
2018 September/October; 66(5):17-19.

Jessica L. Owens
Danielle A. Beaudoin
Christopher J. Spencer
2018 September/October; 66(5):20-23.

Preetha Kanjirath
Larry Williams
2018 September/October; 66(5):24-25.

Galal Omami 
2018 September/October; 66(5):77-78.

Milda Chmieliauskaite
Ivan Stojanov 
Mana Saraghi
Andres Pinto 

Targeted therapies are so-named due to their targeting of dysregulated signaling pathways in cancer cells. This discrimination between tumor and normal cells is a more efficacious approach to treatment than conventional, cytotoxic chemotherapy. However, targeted therapies still have side effects, and some manifest in the oral cavity. This article reviews the oral adverse effects associated with targeted chemotherapeutic agents as well as management approaches.

2018 September/October; 66(5):26-31.

Helena M. Swank
Nancy C. Motyka
Clifton W. Bailey
Kraig S. Vandewalle

This study evaluated the shear bond strength (SBS) of a resin cement to a glass-ceramic material pretreated with combination treatment solutions or the traditional approach of hydrofluoric acid (HF) and silane (control). Pretreatment of the glass ceramic with HF and silane resulted in a significantly greater mean SBS than did any of the combination solutions, which were not significantly different from each other. In the experimental groups with simplified pretreatments, specimen failures were mostly due to adhesive fractures. In the control group the mode of failure was more often mixed adhesive-cohesive fracture.

2018 September/October; 66(5):33-37.

Formation of biofilm on various implant abutment materials
Nasrin Esfahanizadeh  
Seyedeh Pegah Mirmalek
Abbas Bahador
Hamidreza Daneshparvar
Nasrin Akhoundi 
Maryam Pourhajibagher

Biofilm formation induced by bacterial suspensions on laser-treated titanium, zirconia, and titanium surfaces was measured in vitro. The abutment material type, the bacteria type, and their interactions had significant effects on the bacterial counts. The highest counts of periodontal pathogens were found on laser-treated surfaces, while the intermediate and lowest counts were on zirconia and titanium surfaces, respectively.

2018 September/October; 66(5):39-44.

Caroline Nguyen Ngoc
Taneet Ghuman
Sumitha N. Ahmed
Terry E. Donovan

Water enhancers (WEs) have grown in popularity in recent years, but many have a high citric acid content. The purpose of this in vitro study was to determine the erosive potential of 7 WEs mixed in 3 different brands of bottled water. Experiments measured the pH and titratable acidity of the 21 combinations as well as the loss of mass from extracted human molars after 1 month of immersion in the solutions. Regardless of the brands, the addition of a WE to bottled water increased the potential for dental erosion, likely due to the high content of citric acid.

2018 September/October; 66(5):46-51.

Maria L. Geisinger
Amanda B. Morris
Maninder Kaur
Sonya L. Hardy
Ramzi V. Abou Arraj
Nicolaas C. Geurs
Michael S. Reddy

Outcomes for treatment, overall oral health status, and periodontal disease progression in patients with type 2 diabetes mellitus (T2DM) have been associated with glycemic control, as measured by hemoglobin A1c (HbA1c) levels. In this study, 70% of 214 patients who were under the care of a physician for T2DM were found to have an HbA1c level that was not ideal, and 53% of the patients with poor control had HbA1c levels high enough to require medical intervention. Dental healthcare providers should consider consultation and/or advanced screening for T2DM patients seeking dental care.

2018 September/October; 66(5):52-55.

Amber D. Riley

Before treating patients with implantable cardiac devices, dentists must identify the patient’s underlying medical condition and consider both the condition and device during diagnosis and treatment. Modern implantable devices are resistant to electromagnetic field changes, but dentists should use the greatest caution with electrocautery devices and choose a bipolar system whenever possible. Consultation with a patient’s physician is prudent prior to lengthy treatment or use of dental technology that produces an electromagnetic field.

2018 September/October; 66(5):56-60.

Sara Tomczyk
Tory Whitten 
Stacy M. Holzbauer 
Ruth Lynfield

A survey assessing antibiotic-prescribing practices among Minnesota dentists found that a median of 4 antibiotic prophylaxis and 5 treatment prescriptions per month were written by 437 survey respondents. Dentists reported prescribing antibiotics for prophylaxis before invasive dental procedures for patients with “high-risk conditions” (84%) and localized swelling (70%) as well as for a number of reasons that are not recommended by current prescribing guidelines. Antibiotic stewardship efforts in dentistry should address challenges to guideline adherence.

2018 September/October; 66(5):61-68.

Bruno Piazza 
Rodrigo R. Vivan 
Murilo P. Alcalde 
Marco Antonio H. Duarte 
Flaviana B. de Andrade 
Bruno Martini Guimarães 
Clovis M. Bramante

Accidental sodium hypochlorite extrusion during endodontic irrigation can result in severe pain, swelling, and probable tissue necrosis adjacent to the root. Conventional treatment involves saline irrigation as well as analgesic, anti-inflammatory, and antibiotic medications. This case report describes the addition of low-level laser therapy to conventional treatment as a means to improve healing after sodium hypochlorite extrusion caused soft tissue necrosis.

2018 September/October; 66(5):69-72.

Monika Pal
Kanishk Gupta
Santhosh Kumar
Pratibha G

Mandibular tori are an ideal site for harvesting bone because their excision causes no structural, esthetic, or functional compromise to the patient. This case report describes the use of an autogenous graft obtained from a mandibular torus to fill an intrabony defect at the mandibular right central incisor. The torus provided sufficient graft material and eliminated the need for a second surgical site. A follow-up at 1 year revealed reduction in clinical attachment loss and complete resolution of tooth mobility.

2018 September/October; 66(5):73-76.

Eliana Dantas da Costa
Priscila Dias Peyneau 
Liana Matos Ferreira
Matheus Lima Oliveira
Glaucia Maria Bovi Ambrosano 

Osteomas are benign, asymptomatic fibro-osseous tumors that are most commonly observed in the paranasal sinuses. A rare giant osteoma involving the frontal and ethmoid sinuses was found incidentally during a cone beam computed tomographic examination performed for orthodontic reasons. The case report discusses the characteristics of the tumor through cone beam computed tomography as well as options for treatment.

2018 September/October; 66(5):e1-e4.

Fábio Ramôa Pires
Cristiane Bouzada Bruzigueses Espíndola
Sebastião Helberto Ferreira Espíndola 
Juliana de Noronha Santos Netto

A 43-year-old man presented with a slight depression on the lingual surface of the anterior mandible associated with a well-defined radiolucent area superimposed on the roots of the right canine and incisors. All teeth in the area were vital, and cone beam computed tomography revealed a lingual depression in the area. The final diagnosis was an anterior lingual mandibular bone depression, and 22 months of follow-up examinations revealed no alterations in the area. When anterior mandibular radiolucencies are superimposed on the roots of the adjacent teeth, anterior lingual mandibular bone depressions should be considered in the differential diagnosis, along with periapical cysts and granulomas.

2018 September/October; 66(5):e6-e11.

Eliane Cristina Viana Revoredo
André Galembeck 
Elizabeth Arruda Carneiro Ponzi
Jair Carneiro Leão
Leonardo de Siqueira Arcoverde
Luciana Corrêa de Araújo Arcoverde
Sônia Pereira Leite

An immediate obturator is an important aid in the treatment of patients diagnosed with tumors of the head and neck. This case report demonstrates the advantages of using 3-dimensional prototyping in the planning and manufacture of a palatal obturator prosthesis after resection of an ameloblastoma in the left maxillary sinus.

2018 September/October; 66(5):e12-e17.

Roger D. Winland
2018 September/October; 66(5):5.

Mark J. Barnes 
Eliana Dantas da Costa
Gina Delia Roque-Torres
Priscila Dias Peyneau
Luís Roberto Godolfim
Francisco Haiter Neto
Solange Maria de Almeida 
2018 September/October; 66(5):6, 8.

Samuel M. Strong
2018 September/October; 66(5):10-13.

Jason H. Goodchild
Mark Donaldson 
2018 September/October; 66(5):14-16.

Mark I. Malterud
2018 September/October; 66(5):17-19.

Jessica L. Owens
Danielle A. Beaudoin
Christopher J. Spencer
2018 September/October; 66(5):20-23.

Preetha Kanjirath
Larry Williams
2018 September/October; 66(5):24-25.

Galal Omami 
2018 September/October; 66(5):77-78.

Milda Chmieliauskaite
Ivan Stojanov 
Mana Saraghi
Andres Pinto 

Targeted therapies are so-named due to their targeting of dysregulated signaling pathways in cancer cells. This discrimination between tumor and normal cells is a more efficacious approach to treatment than conventional, cytotoxic chemotherapy. However, targeted therapies still have side effects, and some manifest in the oral cavity. This article reviews the oral adverse effects associated with targeted chemotherapeutic agents as well as management approaches.

2018 September/October; 66(5):26-31.

Helena M. Swank
Nancy C. Motyka
Clifton W. Bailey
Kraig S. Vandewalle

This study evaluated the shear bond strength (SBS) of a resin cement to a glass-ceramic material pretreated with combination treatment solutions or the traditional approach of hydrofluoric acid (HF) and silane (control). Pretreatment of the glass ceramic with HF and silane resulted in a significantly greater mean SBS than did any of the combination solutions, which were not significantly different from each other. In the experimental groups with simplified pretreatments, specimen failures were mostly due to adhesive fractures. In the control group the mode of failure was more often mixed adhesive-cohesive fracture.

2018 September/October; 66(5):33-37.

Formation of biofilm on various implant abutment materials
Nasrin Esfahanizadeh  
Seyedeh Pegah Mirmalek
Abbas Bahador
Hamidreza Daneshparvar
Nasrin Akhoundi 
Maryam Pourhajibagher

Biofilm formation induced by bacterial suspensions on laser-treated titanium, zirconia, and titanium surfaces was measured in vitro. The abutment material type, the bacteria type, and their interactions had significant effects on the bacterial counts. The highest counts of periodontal pathogens were found on laser-treated surfaces, while the intermediate and lowest counts were on zirconia and titanium surfaces, respectively.

2018 September/October; 66(5):39-44.

Caroline Nguyen Ngoc
Taneet Ghuman
Sumitha N. Ahmed
Terry E. Donovan

Water enhancers (WEs) have grown in popularity in recent years, but many have a high citric acid content. The purpose of this in vitro study was to determine the erosive potential of 7 WEs mixed in 3 different brands of bottled water. Experiments measured the pH and titratable acidity of the 21 combinations as well as the loss of mass from extracted human molars after 1 month of immersion in the solutions. Regardless of the brands, the addition of a WE to bottled water increased the potential for dental erosion, likely due to the high content of citric acid.

2018 September/October; 66(5):46-51.

Maria L. Geisinger
Amanda B. Morris
Maninder Kaur
Sonya L. Hardy
Ramzi V. Abou Arraj
Nicolaas C. Geurs
Michael S. Reddy

Outcomes for treatment, overall oral health status, and periodontal disease progression in patients with type 2 diabetes mellitus (T2DM) have been associated with glycemic control, as measured by hemoglobin A1c (HbA1c) levels. In this study, 70% of 214 patients who were under the care of a physician for T2DM were found to have an HbA1c level that was not ideal, and 53% of the patients with poor control had HbA1c levels high enough to require medical intervention. Dental healthcare providers should consider consultation and/or advanced screening for T2DM patients seeking dental care.

2018 September/October; 66(5):52-55.

Amber D. Riley

Before treating patients with implantable cardiac devices, dentists must identify the patient’s underlying medical condition and consider both the condition and device during diagnosis and treatment. Modern implantable devices are resistant to electromagnetic field changes, but dentists should use the greatest caution with electrocautery devices and choose a bipolar system whenever possible. Consultation with a patient’s physician is prudent prior to lengthy treatment or use of dental technology that produces an electromagnetic field.

2018 September/October; 66(5):56-60.

Sara Tomczyk
Tory Whitten 
Stacy M. Holzbauer 
Ruth Lynfield

A survey assessing antibiotic-prescribing practices among Minnesota dentists found that a median of 4 antibiotic prophylaxis and 5 treatment prescriptions per month were written by 437 survey respondents. Dentists reported prescribing antibiotics for prophylaxis before invasive dental procedures for patients with “high-risk conditions” (84%) and localized swelling (70%) as well as for a number of reasons that are not recommended by current prescribing guidelines. Antibiotic stewardship efforts in dentistry should address challenges to guideline adherence.

2018 September/October; 66(5):61-68.

Bruno Piazza 
Rodrigo R. Vivan 
Murilo P. Alcalde 
Marco Antonio H. Duarte 
Flaviana B. de Andrade 
Bruno Martini Guimarães 
Clovis M. Bramante

Accidental sodium hypochlorite extrusion during endodontic irrigation can result in severe pain, swelling, and probable tissue necrosis adjacent to the root. Conventional treatment involves saline irrigation as well as analgesic, anti-inflammatory, and antibiotic medications. This case report describes the addition of low-level laser therapy to conventional treatment as a means to improve healing after sodium hypochlorite extrusion caused soft tissue necrosis.

2018 September/October; 66(5):69-72.

Monika Pal
Kanishk Gupta
Santhosh Kumar
Pratibha G

Mandibular tori are an ideal site for harvesting bone because their excision causes no structural, esthetic, or functional compromise to the patient. This case report describes the use of an autogenous graft obtained from a mandibular torus to fill an intrabony defect at the mandibular right central incisor. The torus provided sufficient graft material and eliminated the need for a second surgical site. A follow-up at 1 year revealed reduction in clinical attachment loss and complete resolution of tooth mobility.

2018 September/October; 66(5):73-76.

Eliana Dantas da Costa
Priscila Dias Peyneau 
Liana Matos Ferreira
Matheus Lima Oliveira
Glaucia Maria Bovi Ambrosano 

Osteomas are benign, asymptomatic fibro-osseous tumors that are most commonly observed in the paranasal sinuses. A rare giant osteoma involving the frontal and ethmoid sinuses was found incidentally during a cone beam computed tomographic examination performed for orthodontic reasons. The case report discusses the characteristics of the tumor through cone beam computed tomography as well as options for treatment.

2018 September/October; 66(5):e1-e4.

Fábio Ramôa Pires
Cristiane Bouzada Bruzigueses Espíndola
Sebastião Helberto Ferreira Espíndola 
Juliana de Noronha Santos Netto

A 43-year-old man presented with a slight depression on the lingual surface of the anterior mandible associated with a well-defined radiolucent area superimposed on the roots of the right canine and incisors. All teeth in the area were vital, and cone beam computed tomography revealed a lingual depression in the area. The final diagnosis was an anterior lingual mandibular bone depression, and 22 months of follow-up examinations revealed no alterations in the area. When anterior mandibular radiolucencies are superimposed on the roots of the adjacent teeth, anterior lingual mandibular bone depressions should be considered in the differential diagnosis, along with periapical cysts and granulomas.

2018 September/October; 66(5):e6-e11.

Eliane Cristina Viana Revoredo
André Galembeck 
Elizabeth Arruda Carneiro Ponzi
Jair Carneiro Leão
Leonardo de Siqueira Arcoverde
Luciana Corrêa de Araújo Arcoverde
Sônia Pereira Leite

An immediate obturator is an important aid in the treatment of patients diagnosed with tumors of the head and neck. This case report demonstrates the advantages of using 3-dimensional prototyping in the planning and manufacture of a palatal obturator prosthesis after resection of an ameloblastoma in the left maxillary sinus.

2018 September/October; 66(5):e12-e17.

Roger D. Winland
2018 September/October; 66(5):5.

Mark J. Barnes 
Eliana Dantas da Costa
Gina Delia Roque-Torres
Priscila Dias Peyneau
Luís Roberto Godolfim
Francisco Haiter Neto
Solange Maria de Almeida 
2018 September/October; 66(5):6, 8.

Samuel M. Strong
2018 September/October; 66(5):10-13.

Jason H. Goodchild
Mark Donaldson 
2018 September/October; 66(5):14-16.

Mark I. Malterud
2018 September/October; 66(5):17-19.

Jessica L. Owens
Danielle A. Beaudoin
Christopher J. Spencer
2018 September/October; 66(5):20-23.

Preetha Kanjirath
Larry Williams
2018 September/October; 66(5):24-25.

Galal Omami 
2018 September/October; 66(5):77-78.

Milda Chmieliauskaite
Ivan Stojanov 
Mana Saraghi
Andres Pinto 

Targeted therapies are so-named due to their targeting of dysregulated signaling pathways in cancer cells. This discrimination between tumor and normal cells is a more efficacious approach to treatment than conventional, cytotoxic chemotherapy. However, targeted therapies still have side effects, and some manifest in the oral cavity. This article reviews the oral adverse effects associated with targeted chemotherapeutic agents as well as management approaches.

2018 September/October; 66(5):26-31.

Helena M. Swank
Nancy C. Motyka
Clifton W. Bailey
Kraig S. Vandewalle

This study evaluated the shear bond strength (SBS) of a resin cement to a glass-ceramic material pretreated with combination treatment solutions or the traditional approach of hydrofluoric acid (HF) and silane (control). Pretreatment of the glass ceramic with HF and silane resulted in a significantly greater mean SBS than did any of the combination solutions, which were not significantly different from each other. In the experimental groups with simplified pretreatments, specimen failures were mostly due to adhesive fractures. In the control group the mode of failure was more often mixed adhesive-cohesive fracture.

2018 September/October; 66(5):33-37.

Formation of biofilm on various implant abutment materials
Nasrin Esfahanizadeh  
Seyedeh Pegah Mirmalek
Abbas Bahador
Hamidreza Daneshparvar
Nasrin Akhoundi 
Maryam Pourhajibagher

Biofilm formation induced by bacterial suspensions on laser-treated titanium, zirconia, and titanium surfaces was measured in vitro. The abutment material type, the bacteria type, and their interactions had significant effects on the bacterial counts. The highest counts of periodontal pathogens were found on laser-treated surfaces, while the intermediate and lowest counts were on zirconia and titanium surfaces, respectively.

2018 September/October; 66(5):39-44.

Caroline Nguyen Ngoc
Taneet Ghuman
Sumitha N. Ahmed
Terry E. Donovan

Water enhancers (WEs) have grown in popularity in recent years, but many have a high citric acid content. The purpose of this in vitro study was to determine the erosive potential of 7 WEs mixed in 3 different brands of bottled water. Experiments measured the pH and titratable acidity of the 21 combinations as well as the loss of mass from extracted human molars after 1 month of immersion in the solutions. Regardless of the brands, the addition of a WE to bottled water increased the potential for dental erosion, likely due to the high content of citric acid.

2018 September/October; 66(5):46-51.

Maria L. Geisinger
Amanda B. Morris
Maninder Kaur
Sonya L. Hardy
Ramzi V. Abou Arraj
Nicolaas C. Geurs
Michael S. Reddy

Outcomes for treatment, overall oral health status, and periodontal disease progression in patients with type 2 diabetes mellitus (T2DM) have been associated with glycemic control, as measured by hemoglobin A1c (HbA1c) levels. In this study, 70% of 214 patients who were under the care of a physician for T2DM were found to have an HbA1c level that was not ideal, and 53% of the patients with poor control had HbA1c levels high enough to require medical intervention. Dental healthcare providers should consider consultation and/or advanced screening for T2DM patients seeking dental care.

2018 September/October; 66(5):52-55.

Amber D. Riley

Before treating patients with implantable cardiac devices, dentists must identify the patient’s underlying medical condition and consider both the condition and device during diagnosis and treatment. Modern implantable devices are resistant to electromagnetic field changes, but dentists should use the greatest caution with electrocautery devices and choose a bipolar system whenever possible. Consultation with a patient’s physician is prudent prior to lengthy treatment or use of dental technology that produces an electromagnetic field.

2018 September/October; 66(5):56-60.

Sara Tomczyk
Tory Whitten 
Stacy M. Holzbauer 
Ruth Lynfield

A survey assessing antibiotic-prescribing practices among Minnesota dentists found that a median of 4 antibiotic prophylaxis and 5 treatment prescriptions per month were written by 437 survey respondents. Dentists reported prescribing antibiotics for prophylaxis before invasive dental procedures for patients with “high-risk conditions” (84%) and localized swelling (70%) as well as for a number of reasons that are not recommended by current prescribing guidelines. Antibiotic stewardship efforts in dentistry should address challenges to guideline adherence.

2018 September/October; 66(5):61-68.

Bruno Piazza 
Rodrigo R. Vivan 
Murilo P. Alcalde 
Marco Antonio H. Duarte 
Flaviana B. de Andrade 
Bruno Martini Guimarães 
Clovis M. Bramante

Accidental sodium hypochlorite extrusion during endodontic irrigation can result in severe pain, swelling, and probable tissue necrosis adjacent to the root. Conventional treatment involves saline irrigation as well as analgesic, anti-inflammatory, and antibiotic medications. This case report describes the addition of low-level laser therapy to conventional treatment as a means to improve healing after sodium hypochlorite extrusion caused soft tissue necrosis.

2018 September/October; 66(5):69-72.

Monika Pal
Kanishk Gupta
Santhosh Kumar
Pratibha G

Mandibular tori are an ideal site for harvesting bone because their excision causes no structural, esthetic, or functional compromise to the patient. This case report describes the use of an autogenous graft obtained from a mandibular torus to fill an intrabony defect at the mandibular right central incisor. The torus provided sufficient graft material and eliminated the need for a second surgical site. A follow-up at 1 year revealed reduction in clinical attachment loss and complete resolution of tooth mobility.

2018 September/October; 66(5):73-76.

Eliana Dantas da Costa
Priscila Dias Peyneau 
Liana Matos Ferreira
Matheus Lima Oliveira
Glaucia Maria Bovi Ambrosano 

Osteomas are benign, asymptomatic fibro-osseous tumors that are most commonly observed in the paranasal sinuses. A rare giant osteoma involving the frontal and ethmoid sinuses was found incidentally during a cone beam computed tomographic examination performed for orthodontic reasons. The case report discusses the characteristics of the tumor through cone beam computed tomography as well as options for treatment.

2018 September/October; 66(5):e1-e4.

Fábio Ramôa Pires
Cristiane Bouzada Bruzigueses Espíndola
Sebastião Helberto Ferreira Espíndola 
Juliana de Noronha Santos Netto

A 43-year-old man presented with a slight depression on the lingual surface of the anterior mandible associated with a well-defined radiolucent area superimposed on the roots of the right canine and incisors. All teeth in the area were vital, and cone beam computed tomography revealed a lingual depression in the area. The final diagnosis was an anterior lingual mandibular bone depression, and 22 months of follow-up examinations revealed no alterations in the area. When anterior mandibular radiolucencies are superimposed on the roots of the adjacent teeth, anterior lingual mandibular bone depressions should be considered in the differential diagnosis, along with periapical cysts and granulomas.

2018 September/October; 66(5):e6-e11.

Eliane Cristina Viana Revoredo
André Galembeck 
Elizabeth Arruda Carneiro Ponzi
Jair Carneiro Leão
Leonardo de Siqueira Arcoverde
Luciana Corrêa de Araújo Arcoverde
Sônia Pereira Leite

An immediate obturator is an important aid in the treatment of patients diagnosed with tumors of the head and neck. This case report demonstrates the advantages of using 3-dimensional prototyping in the planning and manufacture of a palatal obturator prosthesis after resection of an ameloblastoma in the left maxillary sinus.

2018 September/October; 66(5):e12-e17.