The development of the first clinically useful antihistamines occurred 80 years ago this year. Diphenhydramine (Benadryl) is the most recognized and ubiquitous, and a new column in General Dentistry reviews its many uses, including as an alternative local anesthetic for patients unable to tolerate amide or ester local anesthetics. 

Learn more about the less explored benefits of diphenhydramine in dentistry.